Acquired Nephrogenic Diabetes Insipidus Causes

The cause of primary central diabetes insipidus is often unknown. Some causes result from an abnormality in the gene responsible for.

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The kidneys filter the blood to remove waste and excess fluid which are stored in the bladder as urine.

Acquired nephrogenic diabetes insipidus causes. Nephrogenic diabetes insipidus ndi is a rare disorder that occurs when the kidneys are unable to concentrate urine. Nephrogenic diabetes insipidus ndi is a rare kidney disorder that may be inherited or acquired. Other causes of acquired nephrogenic diabetes insipidus include.

This is in contrast to central or neurogenic diabetes insipidus which is caused by insufficient levels of antidiuretic hormone adh also called vasopressin. As a result the receptor for adh doesn t function properly. Hypercalcaemia a condition where there s too much calcium in the blood high calcium levels can damage the kidneys hypokalemia a condition where there s not enough potassium in the blood all the cells in the body including.

Ndi is not related to the more common diabetes mellitus sugar diabetes in which the body does not produce or properly use insulin. Nephrogenic diabetes insipidus ndi is defined as the inability of the kidney to concentrate urine owing to the insensitivity of the distal nephron to the antidiuretic hormone arginine vasopressin. Secondary central diabetes insipidus is acquired later in life.

Ndi can be either a congenital or an acquired disorder. The acquired form of nephrogenic diabetes insipidus can result from chronic kidney disease certain medications such as lithium low levels of potassium in the blood hypokalemia high levels of calcium in the blood hypercalcemia or an obstruction of the urinary tract. Ndi is a distinct disorder caused by complete or partial resistance of the kidneys to arginine vasopressin avp.

Nephrogenic diabetes insipidus ndi is a form of diabetes insipidus primarily due to pathology of the kidney. In most people the body balances the fluids you drink with the amount of urine. In infants nephrogenic diabetes insipidus is most commonly caused by an inherited genetic mutation present at birth.

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