Pathophysiology Of Type 2 Diabetes Mellitus Pdf

Insulin resistance largely caused by obesity and physical inactivity both precedes and predicts type 2 diabetes. Type 2 diabetes mellitus is often associated with certain genetic predispositions environmental factors lifestyle choices and the dynamic interactions between all of these different aspects.

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Type 2 diabetes also called non insulin dependent diabetes mellitus niddm is caused by decreased sensitivity of target tissues to insulin.

Pathophysiology of type 2 diabetes mellitus pdf. Classifications of diabetes are credited to the susrata of the hindus the father of medicine in india. The lifetime risk of de veloping type 2 diabetes is 40 if one parent has type 2. The fact that about 80 of people with type 2.

The basic effect of insulin lack or. Key wordstype 2 diabetes impaired insulin secretion insulin resistance. Risk factors are less well defined for type 1 diabetes than for type 2 diabetes but autoimmune genetic and environmental factors are involved in the development of this type of diabetes.

In both types of diabetes mellitus metabolism of all the main foodstuffs is altered. Both type 1 and type 2 diabetes are polygenic diseases where many common variants largely with small effect size contribute to overall disease risk. Diabetes mellitus type 2.

Tion and insulin resistance and environmental factors such as obesity overeating lack of exer cise and stress as well as aging. It is typically a multifactorial disease involving multiple genes and environmental factors to varying extents. Leibel naomi berrie diabetes center 25 february 2008 body mass index chart 25 29 9 overweight.

Pathophysiology of type 2 diabetes mellitus r. That said increasingly type 2 diabetes is being diagnosed in younger people even children. Type 2 diabetes may account for about.

Type 2 diabetes results from an interaction of a subject s genetic makeup 4 and their environment and that with the increasing prevalence of obesity the prevalence of type 2 diabetes is reaching epidemic proportions 5 figure 1. 60 70 years of age. Disease heritability h2 deļ¬ned as sibling relative risk is3 for type 2 diabetes and 15 for type 1 diabetes 17.

The insulin resistance preceding type 2 diabetes is commonly referred to as the metabolic syndrome. Pathophysiology type 2 diabetes normally results from the progressive development of insulin resistance eg in liver and muscle cells and the subsequent dysfunction of pancreatic beta cells. 40 extreme obesity 5 4 height weight lbs 5 2 5 0 5 10 5 8 5 6 6 0 6 2 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 6 4.

Later classifications of diabetes mellitus mellitus is latin for honey sweet are refined and suggested treatments vary from the removal of diuretic food to taking tepid baths. Type 2 type 2 diabetes was previously called non insulin dependent diabetes mellitus niddm or adult onset diabetes. The latter condition consists of a cluster of risk factors which are thought to be either causes or consequences of insulin resistance.

The reduced sensitivity to insulin is often called insulin resistance and its causes are shown in table 1. Various organs play a crucial role in the pathophysiology of type 2 diabetes.

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