Diabetic Neuropathy Mechanism

Symptoms can range from pain and numbness in your feet to problems with the functions of your internal organs such as your heart and bladder. 110 neurotrophic factors and neuronal membrane ion channel dysfunction may likewise play a role in dpn.

Diabeticneuropathy Mechanism For Diabetic Neuropathy Natural

Diabetic neuropathy is a descriptive term that encompasses a spectrum of clinical and subclinical syndromes with differing anatomical distributions clinical courses and possibly differing underlying pathogenetic mechanisms.

Diabetic neuropathy mechanism. That damage called neuropathy may be painful. Numbness tingling or burning sensations extreme sensitivity to touch insensitivity to hot and cold temperatures sharp pain or cramping muscle weakness loss of balance or coordination. There is no single diabetic neuropathy.

The polyol pathway microvascular damage and glycosylation end product theories. Depending on the affected nerves diabetic neuropathy symptoms can range from pain and numbness in your legs and feet to problems with your digestive system urinary tract blood vessels and heart. Diabetes can harm your nerves.

In fact there are numerous data that showed oxidative stress induced tissue injury in the peripheral nerve in experimental diabetes 45 63 88 92 95 98. Diabetic neuropathy is theorized to occur by three mechanisms. As a complication there is an increased risk of injury to the feet because of loss of sensation see diabetic foot.

Diabetic neuropathy most often damages nerves in your legs and feet. The classification of the diabetic neuropathies is not yet finalised and has required successive modifications in the light of accumulating knowledge. It can happen in several ways and they all seem to be related to blood sugar levels being too high for too long.

As a cause of diabetic neuropathy the generation of free radicals is proposed to be a major factor through increased glycolytic process 98 99. Central mechanisms in painful diabetic neuropathy the cellular consequence of the central amplification of peripheral neuronal activity is generally manifested by an exaggerated response to synaptic inputs a reduction in threshold to activate neurons an increased response to suprathreshold stimuli and an expansion of receptive fields jensen and finnerup 2014. A wide variety of syndromes involving the peripheral nerves may be encountered in patients with diabetes mellitus implying a correspondingly diverse range of underlying causative mechanisms.

Diabetic neuropathy diabetic neuropathy is nerve damage that can occur in people with diabetes. These three models most likely act simultaneously but there may also be some overlap between them. At present treatment alleviates pain and can control some associated symptoms but the process is generally progressive.

The mechanisms of diabetic neuropathy are poorly understood. Different types of nerve damage cause different symptoms.

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