Lithium Induced Diabetes Insipidus Treatment

Kim gh lee jw oh yk et al. Amiloride a type of diuretic.

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Several pharmacotherapeutic regimens have been documented as being effective for the management of lithium induced diabetes insipidus including hydrochlorothiazide amiloride indomethacin desmopressin and correction of serum lithium levels.

Lithium induced diabetes insipidus treatment. Arch intern med 1989 149 5 1123 6. Whether it is through alternative medications lower levels of lithium or through the inclusion of additional diuretics and over the counter medications the goal of treatment is to continue providing the emotional stability of lithium while eliminating the diabetes insipidus. Allen hm jackson rl winchester md deck lv allon m.

Supplemental material appendix 1 strobe statement for lithium treatment nephrogenic diabetes insipidus and the risk of hypernatraemia. Most lithium induced cases of diabetes insipidus can be resolved and eliminated over time. Substances lithium carbonate amiloride.

A low sodium diet combined with. Antidiuretic effect of hydrochlorothiazide in lithium induced nephrogenic diabetes insipidus is associated with upregulation of aquaporin 2 na cl co transporter and epithelial sodium channel. Diagnosing lithium induced nephrogenic diabetes insipidus ndi begins with a history of the patient s symptoms and ordering lab tests.

Lithium carbonate is well known for its wide use. Treatment of lithium induced nephrogenic diabetes insipidus depends on a wide interplay of factors and potential options include. A retrospective cohort study by michael ott björn forssén and ursula werneke in therapeutic advances in psychopharmacology.

5 the next step involves a water restriction test also known as a thirst test to measure the patient s ability to concentrate his or her urine. Ball s mccullough j. J am soc nephrol.

Baseline serum osmolality and electrolytes are compared with new values obtained after completing the water restriction test. Indomethacin in the treatment of lithium induced nephrogenic diabetes insipidus.

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